EDI Resource Center

National Council for Prescription Drug Programs (NCPDP SCRIPT)

SCRIPT is a standard developed and maintained by the National Council for Prescription Drug Programs (NCPDP). The standard defines documents for electronic transmission of medical prescriptions in the United States.

Industries Using NCPDP SCRIPT

  • Healthcare
  • Pharmaceuticals
  • Long-term care
  • Health insurance
  • Government

Types of NCPDP SCRIPT Transactions

The SCRIPT standard provides standard EDI document formats for information exchanges between medication prescribers, pharmacies, intermediaries and payers. Some examples include:

  • New prescription request
  • Change of new prescription
  • Cancel of prescription
  • Refill/renewals
  • Resupply in long term care
  • Fill Status notification
  • Medication history exchange


  • NCPDP originally founded in 1976
  • The organization became ANSI-accredited in 1996
  • In 2010, a major release of NCPDP Script gained legislative recognition
  • The SCRIPT standard is renewed and updated regularly by the NCPDP

Governing Body

  • NCPDP, an ANSI-accredited standards development organization, governs the SCRIPT standard
  • NCPDP is a pharmaceutical industry, member-driven organization that's played a major role in landmark legislation, such as HIPAA, the Medicare Prescription Drug Benefit and the Affordable Care Act

NCPDP Transactions List